It may not involve rocket science, but a new X Prize Foundation competition for health care reform could pose the institute’s most daunting challenge yet.

Three weeks before the election, Republicans are growing increasingly concerned about John McCain’s ability to mount a comeback, questioning his tactics and even...

Indianapolis running back Joseph Addai left in the first quarter of Sunday’s game against the Baltimore Ravens with a hamstring injury.

Baltimore Ravens cornerback Fabian Washington will miss Sunday’s game against Indianapolis with a dislocated right shoulder, further thinning a secondary poised...

An illegal immigrant serving five life terms for the strangling deaths of his wife, three young daughters and a neighborhood girl apparently took his own life Thursday...

Democrat Barack Obama’s campaign criticized John McCain’s mortgage bailout plan Wednesday, saying it would cause the government to lose money by paying too...

Democratic presidential candidate Barack Obama is urging Americans not to panic over the faltering economy, saying that better days lie ahead.

Goodyear and NASCAR officials say tire wear has improved significantly during this week’s testing at Indianapolis.

Eli Lilly & Co. has agreed to spend more than $6 billion to fortify its cancer treatment portfolio by acquiring the biotechnology firm ImClone Systems Inc. in a...

Eli Lilly & Co. has agreed to buy biotechnology company ImClone Systems Inc. for more than $6 billion in a deal that would expand Lilly’s cancer treatment...

Federal health regulators delayed a decision on a blood thinner from Eli Lilly for a second time Friday, raising concerns on Wall Street about the potential blockbuster...

The Houston Texans will play their home opener against Indianapolis Oct. 5 in hurricane- damaged Reliant Stadium with the roof open.

The U.S. Army can finish shipping chemical waste from the destruction of a deadly nerve agent in Indiana to an incinerator in Texas, a judge has ruled.

Eli Lilly and Co. aims to grow leaner and more diverse as it pushes to keep pace with changes spreading through the drug industry, CEO John Lechleiter said in a...

Goodyear will test its NASCAR tires at the Indianapolis Motor Speedway twice in the next three weeks as it tries to solve the durability problem it had at the Brickyard...

Two fans at the Grand Prix motorcycle race at Indianapolis Motor Speedway have been injured when a tent collapsed on the infield.

Valentino Rossi of Italy has won the pole position for Sunday’s inaugural Red Bull Indianapolis GP, ending a streak of seven straight poles for Australia’s...

Thomas Luthi of Switzerland avoided serious injuries in a crash during practice Saturday in the 250cc class at the Indianapolis Motor Speedway.

Thomas Luthi of Switzerland has been hospitalized following a crash during practice in the 250 cc motorcycle class at the Indianapolis Motor Speedway.

College slackers in Indiana, beware: Educators want you to earn your degrees in four years or less or it might cost your schools some of their state support.