Betrayed by his big serve, 2003 champion Andy Roddick lost to Novak Djokovic 6-2, 6-3, 3-6, 7-6 (5) in the U.S. Open quarterfinals Thursday night.

Two points from forcing a fifth set at 5-4 in the fourth, Roddick double-faulted twice in a row and was broken for the fifth time _ twice more than he lost serve in his first four matches combined.

The third-seeded Djokovic, the reigning Australian Open champion, advanced to a semifinal meeting against Roger Federer. It’s a rematch of last year’s U.S. Open final, which Federer won for his fourth consecutive title at Flushing Meadows.

Federer beat qualifier Gilles Muller 7-6 (5), 6-4, 7-6 (5) Thursday, extending his own record by reaching the semifinals at an 18th consecutive Grand Slam tournament.